Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204943 | 0.97 | CYP3A4 (0.48) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL2706319 | 0.97 | CYP3A4 (0.48) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL203309 | 0.97 | CYP3A4 (0.48) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL15083853 | 0.96 | CYP3A4 (0.49) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL19488538 | 0.91 | PRCP (0.47) | USP30PRCPHPGDSOPRM1OPRD1 | |
| SCHEMBL205276 | 0.90 | CYP3A4 (0.46) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL205250 | 0.90 | PRCP (0.46) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL2707681 | 0.90 | PRCP (0.46) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL2707737 | 0.90 | CYP3A4 (0.46) | USP30CYP3A4CYP2C9NR1I2ABCB11 | |
| SCHEMBL204202 | 0.90 | PRCP (0.45) | USP30CYP3A4CYP2C9NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601188-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-18 | — | — | EP | disclosed |
| EP-2900656-B1 | SPIRO RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |