Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 4/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 11/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 11/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 5/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887101 | 0.87 | ABL1 (0.37) | KDRABL1TNK2MAP4K2MAPK3 | |
| SCHEMBL1521641 | 0.86 | TNK2 (0.48) | BRAFKDRABL1TNK2MAP4K2 | |
| SCHEMBL1521906 | 0.86 | KCNJ6 (0.46) | BRAFRAF1TNK2MAP4K2MAPK13 | |
| SCHEMBL1521654 | 0.85 | MAPK14 (0.47) | BRAFABL1TNK2MAP4K2MAPK13 | |
| SCHEMBL1521661 | 0.84 | KCNJ6 (0.47) | BRAFRAF1ABL1TNK2MAP4K2 | |
| SCHEMBL1521858 | 0.84 | BRAF (0.46) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521670 | 0.84 | BRAF (0.51) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521734 | 0.83 | MAPK14 (0.51) | BRAFMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1521733 | 0.82 | ABL1 (0.45) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521795 | 0.82 | BRAF (0.47) | BRAFKDRKRASRAF1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118271-A1 | Kinase Inhibitors Useful For The Treatment Of Proliferative Diseases | FLYNN DANIEL L | 2011-05-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118271-A1 | Kinase Inhibitors Useful For The Treatment Of Proliferative Diseases | BRAF, PRKDC, RAF1 | BRAF 1/4885KDR 500/4885KRAS 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.