Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561715 | 0.87 | LPAR1 (0.65) | LPAR1MAOBSIRT2LMNAHTT | |
| SCHEMBL1561352 | 0.86 | LPAR1 (0.77) | LPAR1 | |
| SCHEMBL18832662 | 0.84 | LPAR1 (0.60) | LPAR1MAOBSIRT2LMNAHTT | |
| SCHEMBL13276258 | 0.79 | LPAR1 (0.56) | LPAR1MAOBLMNAHTTMEN1 | |
| SCHEMBL1812189 | 0.78 | LPAR1 (0.64) | LPAR1MAOBNR1H4 | |
| SCHEMBL1561481 | 0.76 | LPAR1 (0.78) | LPAR1MEN1KMT2ANPC1RAB9A | |
| Fipaxalparant SCHEMBL1560214 | 0.76 | LPAR1 (0.78) | LPAR1NPC1RAB9AACHENOX1 | |
| SCHEMBL1560798 | 0.76 | LPAR1 (0.67) | LPAR1SIRT2LMNAMAPTSMN1; SMN2 | |
| Fipaxalparant SCHEMBL29382253 | 0.76 | LPAR1 (0.78) | LPAR1NPC1RAB9AACHENOX1 | |
| SCHEMBL1561405 | 0.76 | LPAR1 (0.67) | LPAR1SIRT2NPC1RAB9AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303270-B1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-17 | — | — | EP | disclosed |