Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.60 |
| ▸ | TLR9 | Q9NR96 | 13/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18879482 | 1.00 | TLR8 (0.60) | TLR8TLR9TLR7ARNSD2 | |
| Hydrochloric Acid SCHEMBL17840531 | 0.99 | TLR8 (0.59) | TLR8TLR9TLR7ARNSD2 | |
| Hydrochloric Acid SCHEMBL17840529 | 0.99 | TLR8 (0.59) | TLR8TLR9TLR7ARNSD2 | |
| SCHEMBL19000090 | 0.87 | TLR8 (0.63) | TLR8TLR9TLR7ARNSD2 | |
| SCHEMBL23855164 | 0.87 | TLR8 (0.63) | TLR8TLR9TLR7ARNSD2 | |
| SCHEMBL18980745 | 0.86 | TLR8 (0.43) | TLR8TLR9TLR7 | |
| SCHEMBL18980747 | 0.86 | TLR8 (0.43) | TLR8TLR9TLR7 | |
| Hydrochloric Acid SCHEMBL18980484 | 0.86 | TLR8 (0.62) | TLR8TLR9TLR7ARNSD2 | |
| Hydrochloric Acid SCHEMBL18980842 | 0.85 | TLR8 (0.43) | TLR8TLR9TLR7 | |
| SCHEMBL16653627 | 0.81 | TLR8 (0.45) | TLR8TLR9TLR7ARRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057948-B1 | SELECTIVELY SUBSTITUTED QUINOLINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2018-03-14 | — | — | EP | claimed |
| US-9663486-B2 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-05-30 | — | — | US | claimed |