Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 15/20 | 0.74 |
| ▸ | KDM5C | P41229 | 9/20 | 0.74 |
| ▸ | KDM5A | P29375 | 7/20 | 0.72 |
| ▸ | KDM4A | O75164 | 3/20 | 0.72 |
| ▸ | KDM6B | O15054 | 1/20 | 0.72 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.72 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.71 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364565 | 0.91 | KDM5B (0.75) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15994347 | 0.89 | KDM5B (0.73) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16293178 | 0.88 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL19574688 | 0.86 | KDM5B (0.69) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15994301 | 0.85 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17364566 | 0.84 | KDM5B (0.87) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636679 | 0.84 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15994214 | 0.84 | KDM5B (0.72) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16292435 | 0.83 | KDM5B (0.85) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL25380189 | 0.83 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961736-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |