Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15228309 | 0.91 | MAPT (0.82) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL16429075 | 0.90 | MAPT (0.80) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL16441166 | 0.88 | MAPT (0.68) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL15244857 | 0.87 | MAPT (0.73) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL15228617 | 0.87 | MAPT (0.82) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL29353512 | 0.87 | MAPT (0.82) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL18888491 | 0.85 | MAPT (0.71) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL18883299 | 0.84 | MAPT (0.77) | MAPTTP53POLBGRM5HCRTR1 | |
| SCHEMBL15228394 | 0.84 | MAPT (0.70) | MAPTTP53POLBGRM5KDM4E | |
| SCHEMBL15228461 | 0.83 | MAPT (0.72) | MAPTTP53POLBGRM5PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657013-B2 | Inhibitors of hepatitis B virus covalently closed circular DNA formation and their method of use | BARUCH S. BLUMBERG INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |