SCHEMBL188841

SCHEMBL188841

Nc1ncc(Br)cc1O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29857912 1.00
SCHEMBL29849628 0.75
SCHEMBL621291 0.75
SCHEMBL30420165 0.75
SCHEMBL1577450 0.75
SCHEMBL30421035 0.75
SCHEMBL9198455 0.75
SCHEMBL971307 0.75
SCHEMBL17255919 0.75 KMT2A (0.65)
SCHEMBL29636055 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 451 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111943885-B Synthesis method of Laratinib intermediate 2-amino-5-bromo-3-hydroxypyridine 西华大学 2023-08-04 CN claimed
CN-111943885-A Synthetic method of Laolatinib intermediate 2-amino-5-bromo-3-hydroxypyridine 西华大学 2020-11-17 CN claimed
CN-109942485-A A kind of gram of azoles replaces the synthetic method of Buddhist nun's intermediate 青岛前线生物工程有限公司 2019-06-28 CN claimed
CN-104910152-A 6-Bromo-8-methoxy-phenyl ketone imidazo [1,2a] pyridin-3-phenyl ketone synthetic method SHANDONG YOUBANG BIOCHEMICAL TECHNOLOGY CO LTD 2015-09-16 CN claimed
CN-104910157-A 6-bromo-8-acetonitrile oxy imidazo [1,2-a] pyridine-3-carbonitrile preparation method SHANDONG YOUBANG BIOCHEMICAL TECHNOLOGY CO LTD 2015-09-16 CN claimed
CN-104844599-A Synthesis method of 6-bromine-8-methoxy ethyl formate imidazole and [1,2a]pyridine-3-ethyl formate SHANDONG YOUBANG BIOCHEMICAL TECHNOLOGY CO LTD 2015-08-19 CN claimed
CN-103772272-A Synthetic method of 2-BOC-amido-3-hydroxy-5-bromopyridine DINGTAO COUNTY YOUBANG CHEMICAL INDUSTRY CO LTD 2014-05-07 CN claimed
CN-103772382-A 6-bromine-8-hydroxyl-imidazo (1, 2a) pyridine hydrochloride and synthetic method thereof DINGTAO COUNTY YOUBANG CHEMICAL INDUSTRY CO LTD 2014-05-07 CN claimed
CN-1803802-A Method for synthesizing oxazole pyridone compound FUJIAN MATTER STRUCTURE (CN) 2006-07-19 CN claimed
US-20260102395-A1 INHIBITING HISTONE DEACETYLASE 6 EIKONIZO THERAPEUTICS, INC. (US) 2026-04-16 US disclosed
US-12577217-B2 15-PGDH inhibitor KYORIN PHARMACEUTICAL CO., LTD. (JP) 2026-03-17 US disclosed
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 GILEAD SCIENCES INC (US) 2025-11-06 US disclosed
US-20250325677-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2025-10-23 US disclosed
EP-4626881-A1 PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS Merck Sharp & Dohme LLC (US) 2025-10-08 EP disclosed
US-4224025-A Process for the dyeing and printing of paper materials in different hues using a single coupling component CIBA-GEIGY CORPORATION (US) 1980-09-23 US disclosed
US-4193916-A Sulfo- or carboxy-aryl amino sulfonyl phenyl azo hydroxpyridine heavy metal complex dyes CIBA-GEIGY CORPORATION (US) 1980-03-18 US disclosed
US-RE29585-E DYEING WOOL CIBA-GEIGY CORPORATION (US) 1978-03-21 US disclosed
US-4033975-A Process for the production of 2-amino-3-hydroxypyridine derivatives CIBA-GEIGY CORPORATION (US) 1977-07-05 US disclosed
US-4033975-A Process for the production of 2-amino-3-hydroxypyridine derivatives CIBA-GEIGY CORPORATION (US) 1977-07-05 US disclosed
US-4022897-A 4H-PYRIDO(1,2-A) PYRIMIDIN-4-ONE DERIVATIVES E. R. SQUIBB & SONS, INC. (US) 1977-05-10 US disclosed