Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18891976 | 0.88 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1CNR1ERN1 | |
| SCHEMBL18891993 | 0.86 | KDM4E (0.46) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL20021112 | 0.84 | KDM4E (0.47) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL18892448 | 0.83 | KDM4E (0.44) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL18891801 | 0.82 | GSK3B (0.47) | KDM4E | |
| SCHEMBL18892343 | 0.81 | KDM4E (0.46) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL18891803 | 0.79 | KDM4E (0.44) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL3297610 | 0.77 | KDM4E (0.54) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL3303954 | 0.76 | KDM4E (0.53) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 | |
| SCHEMBL20021122 | 0.75 | KDM4E (0.52) | KDM4ESMN1; SMN2PTGDR2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588450-B1 | NAPHT-2-YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES INC (US) | 2017-05-24 | — | — | EP | disclosed |