Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.75 |
| ▸ | FGFR4 | P22455 | 14/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16071658 | 0.95 | FGFR1 (0.74) | FGFR1FGFR4FGFR2EGFRFGFR3 | |
| SCHEMBL18895840 | 0.93 | FGFR1 (0.82) | FGFR1FGFR4FGFR2EGFRFGFR3 | |
| SCHEMBL16071654 | 0.89 | FGFR1 (0.77) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16071655 | 0.88 | FGFR1 (0.81) | FGFR1FGFR4FGFR2EGFRFGFR3 | |
| SCHEMBL16071656 | 0.87 | FGFR1 (0.73) | FGFR1FGFR4FGFR2EGFRFGFR3 | |
| SCHEMBL21166354 | 0.86 | FGFR1 (0.60) | FGFR1FGFR4FGFR2EGFR | |
| SCHEMBL15413160 | 0.86 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL21860479 | 0.86 | FGFR1 (0.75) | FGFR1FGFR4FGFR2EGFRFGFR3 | |
| SCHEMBL16071668 | 0.85 | FGFR1 (0.68) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16071644 | 0.85 | FGFR1 (0.74) | FGFR1FGFR4FGFR2EGFRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968337-B1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2021-07-21 | — | — | EP | disclosed |
| US-9695132-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-07-04 | — | — | US | disclosed |
| US-9663524-B2 | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors | CELGENE CAR LLC (BM) | 2017-05-30 | — | — | US | disclosed |