Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14420045 | 0.88 | CCR1 (0.40) | CCR1DRD2DRD4CHRM2CCR5 | |
| SCHEMBL13824459 | 0.81 | CCR1 (0.40) | CCR1CHRM2CCR5 | |
| SCHEMBL18896006 | 0.80 | CCR1 (0.33) | CCR1 | |
| SCHEMBL13824447 | 0.80 | CCR1 (0.39) | CCR1CHRM2CCR5 | |
| SCHEMBL18896010 | 0.80 | CCR1 (0.39) | CCR1CHRM2CCR5 | |
| SCHEMBL654879 | 0.80 | CCR1 (0.60) | CCR1DRD2DRD4CHRM2CCR5 | |
| SCHEMBL15478318 | 0.80 | CCR1 (0.60) | CCR1DRD2DRD4CHRM2CCR5 | |
| SCHEMBL654878 | 0.80 | CCR1 (0.60) | CCR1DRD2DRD4CHRM2CCR5 | |
| SCHEMBL18895962 | 0.79 | CCR1 (0.39) | CCR1CHRM2CCR5 | |
| SCHEMBL15478420 | 0.79 | CCR1 (0.37) | CCR1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |