Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 6/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15478358 | 0.92 | CCR1 (0.54) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10288256 | 0.91 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL12121719 | 0.88 | CCR1 (0.54) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10288250 | 0.86 | CCR1 (0.53) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14420032 | 0.86 | CCR1 (0.53) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10287596 | 0.85 | CCR1 (0.52) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL15478344 | 0.85 | CCR1 (0.59) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14579621 | 0.85 | CCR1 (0.54) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL15478347 | 0.85 | CCR1 (0.51) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL15478312 | 0.84 | CCR1 (0.48) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |