Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | ADH1B | P00325 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.32 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13067947 | 1.00 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL22296768 | 0.95 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL13068259 | 0.95 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL31076284 | 0.95 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL19077679 | 0.95 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL21091821 | 0.95 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL23961107 | 0.91 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL21091828 | 0.91 | TSHR (0.56) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL1958993 | 0.89 | TSHR (0.54) | TSHRACE2LMNADNM1OPRM1 | |
| SCHEMBL25126675 | 0.89 | TSHR (0.54) | TSHRACE2LMNADNM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |