Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18896717 | 0.86 | PIK3CG (0.57) | PIK3CGPIK3CAPIK3CDPIK3CBNPC1 | |
| SCHEMBL1932313 | 0.84 | TTK (0.60) | TTKPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL9997048 | 0.84 | PIK3CG (0.47) | TTKPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL1933562 | 0.83 | TTK (0.62) | TTKPIK3CGPIK3CDNPC1RAB9A | |
| SCHEMBL13731733 | 0.82 | PIK3CD (0.51) | TTKPIK3CGPIK3CAPIK3CDNPC1 | |
| SCHEMBL12070691 | 0.82 | TTK (0.61) | TTKMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12506777 | 0.80 | TTK (0.60) | TTKPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL13731580 | 0.79 | TTK (0.48) | TTKPIK3CGPIK3CAPIK3CDMAPT | |
| SCHEMBL13732913 | 0.78 | TTK (0.47) | TTKPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL15036967 | 0.77 | TTK (0.52) | TTKPIK3CGPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663510-B2 | Substituted triazolopyridines and their use as TTK inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |