Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 13/20 | 0.58 |
| ▸ | FLT1 | P17948 | 13/20 | 0.58 |
| ▸ | KDR | P35968 | 13/20 | 0.58 |
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | FLT4 | P35916 | 11/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | CCR4 | P51679 | 3/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896917 | 1.00 | FGFR1 (0.58) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL1885305 | 1.00 | FGFR1 (0.58) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL7738591 | 0.79 | KDR (0.61) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL1467578 | 0.73 | KDR (1.00) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL1469920 | 0.73 | KDR (1.00) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL1467082 | 0.73 | KDR (1.00) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL13144544 | 0.72 | CCR4 (0.64) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL13144560 | 0.71 | CCR4 (0.63) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL13144550 | 0.71 | CCR4 (0.63) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL3095907 | 0.71 | CCR4 (0.63) | FGFR1FLT1KDREGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42353-E1 | Quinazoline derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2011-05-10 | — | — | US | claimed |
| US-6414148-B1 | PRODUCE ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT IN WARM-BLOODED ANIMALS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | claimed |