Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16071425 | 0.80 | FGFR4 (0.69) | FGFR4AURKACCNA2CDK2PLK1 | |
| SCHEMBL16072330 | 0.73 | FGFR4 (0.71) | FGFR4AURKACCNA2CDK2PLK1 | |
| SCHEMBL18897360 | 0.72 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071435 | 0.70 | FGFR4 (0.77) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071550 | 0.70 | FGFR4 (1.00) | FGFR4FGFR1EGFRFGFR2FGFR3 | |
| SCHEMBL16071525 | 0.69 | FGFR4 (0.75) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21860422 | 0.68 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16133986 | 0.68 | FGFR4 (1.00) | FGFR4FGFR1EGFRFGFR2FGFR3 | |
| SCHEMBL18897357 | 0.66 | FGFR1 (0.65) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL19360717 | 0.66 | FGFR4 (0.75) | FGFR4FGFR1EGFRFGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663524-B2 | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors | CELGENE CAR LLC (BM) | 2017-05-30 | — | — | US | disclosed |