Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22326393 | 1.00 | MAOB (0.42) | MAOBPAOXDAOHRH3SLC6A4 | |
| SCHEMBL23919485 | 0.87 | MAOB (0.41) | MAOBDAOSLC2A1KDM1ASIGMAR1 | |
| SCHEMBL26381190 | 0.87 | PAOX (0.36) | PAOXKDM1ASIGMAR1KDM4EMEN1 | |
| SCHEMBL20850613 | 0.86 | MAOB (0.40) | MAOBDAOHRH3SLC6A4SLC2A1 | |
| SCHEMBL24309020 | 0.86 | MAOB (0.40) | MAOBDAOHRH3SLC2A1KDM1A | |
| SCHEMBL22337368 | 0.84 | MAOB (0.39) | MAOBDAOHRH3SLC2A1KDM1A | |
| SCHEMBL23489955 | 0.84 | MAOB (0.39) | MAOBDAOSLC2A1KDM1AMAOA | |
| SCHEMBL23132687 | 0.84 | MC4R (0.36) | MAOBDAOHRH3KDM1AKDM4E | |
| SCHEMBL8975798 | 0.82 | MAOB (0.40) | MAOBHRH3KDM4EMEN1KMT2A | |
| SCHEMBL25700799 | 0.82 | KDM4E (0.40) | PAOXKDM1ASIGMAR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663533-B2 | Thieno[3,2-C]pyridin-4(5H)-ones as BET inhibitors | GLAXOSMITHKLINE LLC (US) | 2017-05-30 | — | — | US | disclosed |