Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17841291 | 0.91 | CYP3A4 (0.53) | CYP3A4CYP2B6PGRHTTSMN1; SMN2 | |
| SCHEMBL17841290 | 0.91 | CYP3A4 (0.53) | CYP3A4CYP2B6PGRHTTSMN1; SMN2 | |
| SCHEMBL17857500 | 0.82 | CYP3A4 (0.44) | CYP3A4CYP2B6PGRHTTSMN1; SMN2 | |
| SCHEMBL17841304 | 0.76 | CYP3A4 (0.69) | CYP3A4CYP2B6HTTSMN1; SMN2POLB | |
| SCHEMBL17841303 | 0.76 | CYP3A4 (0.69) | CYP3A4CYP2B6HTTSMN1; SMN2POLB | |
| SCHEMBL16320779 | 0.74 | CYP3A4 (0.69) | CYP3A4CYP2B6HTTSMN1; SMN2POLB | |
| SCHEMBL16320781 | 0.74 | CYP3A4 (0.69) | CYP3A4CYP2B6HTTSMN1; SMN2POLB | |
| SCHEMBL18898410 | 0.73 | CYP3A4 (0.35) | CYP3A4CYP2B6PGRPDPK1 | |
| SCHEMBL16322089 | 0.72 | CYP3A4 (0.70) | CYP3A4CYP2B6HTTSMN1; SMN2POLB | |
| SCHEMBL16322092 | 0.72 | CYP3A4 (0.70) | CYP3A4CYP2B6HTTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663516-B2 | Bicyclic-pyrimidinedione compounds | MyoKardia, Inc. (US) | 2017-05-30 | — | — | US | disclosed |