Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | IL1B | P01584 | 1/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PDE6D | O43924 | 6/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282861 | 1.00 | CRBN (0.57) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL328547 | 0.99 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283958 | 0.93 | CRBN (0.60) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL286218 | 0.87 | CRBN (0.66) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283111 | 0.87 | CRBN (0.58) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282263 | 0.86 | CRBN (0.64) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL283467 | 0.86 | CRBN (0.59) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL284416 | 0.86 | CRBN (0.59) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL328600 | 0.86 | CRBN (0.59) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL18946375 | 0.85 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428513-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |
| EP-2420498-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |