Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | IL1B | P01584 | 1/20 | 0.50 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12638455 | 0.85 | CRBN (0.47) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL19525976 | 0.84 | DDB1 (0.60) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638426 | 0.82 | DDB1 (0.51) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL25565711 | 0.81 | DDB1 (0.56) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638463 | 0.80 | DDB1 (0.46) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638428 | 0.80 | CRBN (0.49) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638449 | 0.79 | DDB1 (0.47) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL16768175 | 0.79 | DDB1 (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638348 | 0.79 | DDB1 (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL12638470 | 0.79 | CRBN (0.46) | CRBNDDB1TNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428513-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |