Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 9/20 | 0.74 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18900837 | 0.88 | CMA1 (0.77) | CMA1POLB | |
| SCHEMBL7960524 | 0.85 | CMA1 (1.00) | CMA1GPR84POLBKDM4E | |
| SCHEMBL7961041 | 0.83 | CMA1 (0.80) | CMA1GPR84KDM4EHSD17B10 | |
| SCHEMBL3418056 | 0.79 | CMA1 (1.00) | CMA1GPR84POLBKDM4E | |
| SCHEMBL18900854 | 0.79 | CMA1 (0.76) | CMA1GPR84HTR2A | |
| SCHEMBL7966175 | 0.76 | CMA1 (0.81) | CMA1GPR84POLBKDM4EHPGD | |
| SCHEMBL7951279 | 0.74 | CMA1 (1.00) | CMA1 | |
| SCHEMBL7951727 | 0.74 | CMA1 (1.00) | CMA1GPR84 | |
| SCHEMBL7960485 | 0.73 | CMA1 (0.84) | CMA1 | |
| SCHEMBL7959067 | 0.73 | CMA1 (0.85) | CMA1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323991-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |