⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8388694 | 0.86 | — | — | |
| SCHEMBL20755077 | 0.86 | — | — | |
| SCHEMBL1785878 | 0.80 | POLB (0.36) | — | |
| SCHEMBL28300320 | 0.75 | MAPT (0.44) | — | |
| SCHEMBL12845869 | 0.74 | — | — | |
| SCHEMBL2040652 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL15464406 | 0.72 | — | — | |
| SCHEMBL10273176 | 0.70 | — | — | |
| SCHEMBL762438 | 0.70 | — | — | |
| SCHEMBL13193928 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2019027890-A1 | METHODS FOR TREATING MYELOSUPPRESSION | GAFFNEY KEVIN J (US) | 2019-02-07 | — | — | WO | disclosed |
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |