SCHEMBL18901563

SCHEMBL18901563

CC(N)COc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 20/20 0.67
MKNK2 Q9HBH9 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14771503 1.00 MKNK1 (0.67) MKNK1MKNK2
SCHEMBL18901588 0.90 MKNK1 (0.65) MKNK1MKNK2
SCHEMBL14764377 0.87 MKNK1 (0.78) MKNK1MKNK2
SCHEMBL13859558 0.87 MKNK1 (0.78) MKNK1MKNK2
SCHEMBL14771434 0.87 MKNK1 (0.78) MKNK1MKNK2
SCHEMBL14764110 0.87 MKNK1 (0.60) MKNK1MKNK2
SCHEMBL18901315 0.85 MKNK1 (0.77) MKNK1MKNK2
SCHEMBL14771332 0.85 MKNK1 (0.77) MKNK1MKNK2
SCHEMBL16278529 0.85 MKNK1 (0.66) MKNK1MKNK2
SCHEMBL16278939 0.85 MKNK1 (0.66) MKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2758401-B1 AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES BAYER IP GMBH (DE) 2017-05-31 EP disclosed