Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 19/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18381105 | 0.91 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL14406287 | 0.91 | TRPV1 (0.76) | TRPV1 | |
| SCHEMBL18902119 | 0.91 | TRPV1 (0.76) | TRPV1 | |
| SCHEMBL14945223 | 0.91 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL12074317 | 0.91 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL14406288 | 0.90 | TRPV1 (0.77) | TRPV1 | |
| SCHEMBL14406328 | 0.90 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL14406327 | 0.89 | TRPV1 (0.77) | TRPV1 | |
| SCHEMBL14406216 | 0.88 | TRPV1 (0.76) | TRPV1 | |
| SCHEMBL14406295 | 0.88 | TRPV1 (0.78) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173411-B1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA LP (US) | 2018-05-09 | — | — | EP | disclosed |
| EP-3173411-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | Purdue Pharma L.P. (US) | 2017-05-31 | — | — | EP | disclosed |