Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19807568 | 0.83 | KCNH2 (0.61) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| SCHEMBL21702872 | 0.83 | KCNH2 (0.61) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| SCHEMBL18231280 | 0.83 | KCNH2 (0.61) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| SCHEMBL22624261 | 0.83 | KCNH2 (0.61) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| SCHEMBL18231284 | 0.83 | KCNH2 (0.61) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| SCHEMBL17018784 | 0.83 | KCNH2 (0.49) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| SCHEMBL18902191 | 0.82 | KCNH2 (0.48) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL17969203 | 0.82 | KCNH2 (0.61) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL17006378 | 0.82 | KCNH2 (0.50) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL17969204 | 0.75 | KCNH2 (0.49) | KCNH2CYP2C9CYP2C19CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900674-B1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2017-05-31 | — | — | EP | disclosed |