Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 18/20 | 0.56 |
| ▸ | GCK | P35557 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15748 | 1.00 | GCKR (0.56) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL14899161 | 1.00 | GCKR (0.56) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL12089583 | 0.92 | MAPT (0.46) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL12089903 | 0.92 | MAPT (0.46) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL19488 | 0.90 | GCKR (0.58) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL15835 | 0.90 | GCKR (0.58) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL20260 | 0.90 | GCKR (0.58) | GCKRGCKGAAMAPTTSHR | |
| SCHEMBL17077 | 0.89 | GCKR (0.56) | GCKRGCK | |
| SCHEMBL16409 | 0.89 | GCKR (0.56) | GCKRGCK | |
| SCHEMBL16968 | 0.89 | GCKR (0.56) | GCKRGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431563-B2 | Compounds that interact with glucokinase regulatory protein for the treatment of diabetes | AMGEN INC. (US) | 2013-04-30 | — | — | US | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |