Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | TSPO | P30536 | 1/20 | 0.73 |
| ▸ | BRD2 | P25440 | 9/20 | 0.67 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.67 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.67 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | BRD1 | O95696 | 1/20 | 0.61 |
| ▸ | CCL2 | P13500 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | EP300 | Q09472 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | DNER | Q8NFT8 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908642 | 1.00 | BRD4 (0.73) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908700 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908694 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908712 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908701 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908713 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908690 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908714 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908698 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 | |
| SCHEMBL18908695 | 0.99 | BRD4 (0.72) | BRD4ADORA3TSPOBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119416-A9 | BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-21 | — | — | US | disclosed |
| US-20210221826-A1 | BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-07-22 | — | — | US | disclosed |
| US-10913752-B2 | Bivalent bromodomain inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200172553-A9 | BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-06-04 | — | — | US | disclosed |
| WO-2017091673-A2 | BIVALENT BROMODOMAIN INHIBTORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221826-A1 | BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF | BRD4, BET1, BRD2 | BRD4 1/4885ADORA3 3906/4885TSPO 3124/4885 |
| US-10913752-B2 | Bivalent bromodomain inhibitors and uses thereof | BRD4, BRD2, BET1 | BRD4 1/4885ADORA3 3948/4885TSPO 3333/4885 |
| US-20200172553-A9 | BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF | BRD4, BET1, BRD2 | BRD4 1/4885ADORA3 4091/4885TSPO 3246/4885 |
| US-20220119416-A9 | BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF | BRD4, BET1, BRD2 | BRD4 1/4885ADORA3 3906/4885TSPO 3124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.