Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 10/20 | 0.54 |
| ▸ | FLT4 | P35916 | 10/20 | 0.54 |
| ▸ | KDR | P35968 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | CCR9 | P51686 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | RRM1 | P23921 | 2/20 | 0.38 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370309 | 0.88 | FLT1 (0.64) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL4370235 | 0.87 | FLT1 (0.63) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL1891073 | 0.86 | CCR9 (0.38) | FLT1FLT4KDRALDH1A1CCR9 | |
| SCHEMBL1887848 | 0.85 | FLT1 (0.47) | FLT1FLT4KDRALDH1A1CCR9 | |
| SCHEMBL4371951 | 0.84 | FLT1 (0.61) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL4374523 | 0.83 | FLT1 (0.60) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL1884479 | 0.82 | FLT1 (0.59) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL4370395 | 0.82 | FLT1 (0.59) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL1883205 | 0.81 | FLT1 (0.58) | FLT1FLT4KDRALDH1A1AVPR2 | |
| SCHEMBL1891645 | 0.81 | FLT1 (0.57) | FLT1FLT4KDRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939532-B2 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | claimed |
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | claimed |
| EP-2079719-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-22 | — | — | EP | claimed |
| WO-2008049605-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-02 | — | — | WO | claimed |
| US-7939532-B2 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | disclosed |
| EP-2079719-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008049605-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | STS, TPMT, DPYD | FLT1 3357/4885FLT4 3694/4885KDR 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.