SCHEMBL18912928

SCHEMBL18912928

Cc1ccc(N/N=C\C=N)c(C(=O)N2CC3CN(c4ncc(-c5ccccc5C(N)=O)cn4)CC3C2)c1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 20/20 0.45
HCRTR1 O43613 18/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18912820 0.84 HCRTR1 (0.48) HCRTR2HCRTR1
SCHEMBL18912802 0.79 HCRTR2 (0.66) HCRTR2HCRTR1
SCHEMBL18910771 0.79 HCRTR2 (0.64) HCRTR2HCRTR1
SCHEMBL18910857 0.77 HCRTR2 (0.52) HCRTR2HCRTR1
SCHEMBL18910776 0.76 HCRTR2 (0.54) HCRTR2HCRTR1
SCHEMBL20976806 0.75 HCRTR1 (0.61) HCRTR2HCRTR1
SCHEMBL20976771 0.75 CHRNA4 (0.45) HCRTR2HCRTR1
SCHEMBL18910715 0.73 HCRTR2 (0.53) HCRTR2HCRTR1
SCHEMBL18912804 0.72 HCRTR1 (0.64) HCRTR2HCRTR1
SCHEMBL20976798 0.71 HCRTR1 (0.61) HCRTR2HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017088731-A1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND USE THEREOF 广东东阳光药业有限公司 2017-06-01 WO disclosed