Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPA | Q15257 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891781 | 0.93 | ANO1 (0.47) | TP53ANO1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1952335 | 0.85 | ANO1 (0.46) | TP53ANO1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1895875 | 0.83 | TP53 (0.52) | TP53ANO1MAPTALDH1A1LMNA | |
| SCHEMBL1951770 | 0.81 | ANO1 (0.48) | TP53ANO1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1896646 | 0.77 | MEN1 (0.42) | TP53ANO1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1950605 | 0.76 | ANO1 (0.46) | ANO1MEN1KMT2A | |
| SCHEMBL1895872 | 0.75 | ANO1 (0.52) | TP53ANO1MAPTMEN1KMT2A | |
| SCHEMBL1950114 | 0.74 | ANO1 (0.52) | ANO1MEN1KMT2ARAB9A | |
| SCHEMBL1953087 | 0.74 | MEN1 (0.55) | TP53ANO1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1954204 | 0.73 | MEN1 (0.47) | TP53ANO1ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |