Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 18/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21874635 | 0.99 | SLC6A2 (0.52) | SLC6A2SLC6A4USP30SLC6A3CYP2D6 | |
| SCHEMBL3619850 | 0.76 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL31470002 | 0.75 | USP2 (0.65) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL7343934 | 0.72 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL8485439 | 0.72 | HTR2C (0.47) | SLC6A2SLC6A4USP30CYP2D6 | |
| SCHEMBL25137428 | 0.71 | CA12 (0.55) | USP30 | |
| SCHEMBL9789594 | 0.70 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL20606457 | 0.70 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL1968845 | 0.70 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL20605786 | 0.70 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383859-A1 | 1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30. | Mission Therapeutics Limited (GB) | 2018-10-10 | — | — | EP | disclosed |
| WO-2017093718-A1 | 1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30. | MISSION THERAPEUTICS LIMITED (GB) | 2017-06-08 | — | — | WO | disclosed |