Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 5/20 | 0.97 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.97 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.97 |
| ▸ | SHBG | P04278 | 2/20 | 0.97 |
| ▸ | PGR | P06401 | 2/20 | 0.97 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.97 |
| ▸ | AR | P10275 | 2/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.97 |
| ▸ | SNCA | P37840 | 2/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol SCHEMBL1888748 | 1.00 | ESR1 (0.97) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL19217062 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL7260525 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL13252493 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL10039358 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL24037697 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL18258335 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL961326 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL7037626 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR | |
| Estradiol SCHEMBL15610524 | 0.99 | ESR1 (1.00) | ESR1LMNAESR2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110236667-A1 | POLYURETHANE-MODIFIED ALKYD RESIN DISPERSIONS | BAYER MATERIALSCIENCE AG (DE) | 2011-09-29 | — | — | US | claimed |
| US-20080146748-A1 | Polyurethane-modified alkyd resin dispersions | BAYER MATERIALSCIENCE AG (DE) | 2008-06-19 | — | — | US | claimed |
| CN-101186683-A | Polyurethane-modified alkyd resin dispersions | BAYER MATERIALSCIENCE AG (DE) | 2008-05-28 | — | — | CN | claimed |
| CN-110093168-B | Liquid crystal aligning agent, liquid crystal alignment film and liquid crystal display device | 夏普株式会社 | 2022-10-21 | — | — | CN | disclosed |
| US-10809574-B2 | Liquid crystal alignment agent, liquid crystal alignment film, and liquid crystal display device | SHARP KABUSHIKI KAISHA (JP) | 2020-10-20 | — | — | US | disclosed |
| US-20190233731-A1 | LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY DEVICE | SHARP KABUSHIKI KAISHA (JP) | 2019-08-01 | — | — | US | disclosed |
| US-20110256092-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110236667-A1 | POLYURETHANE-MODIFIED ALKYD RESIN DISPERSIONS | BAYER MATERIALSCIENCE AG (DE) | 2011-09-29 | — | — | US | disclosed |
| US-7939546-B2 | Quinoline derivatives for modulating DNA methylation | SUPERGEN, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7790746-B2 | Quinoline derivatives for modulating DNA methylation | SUPERGEN, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-2205586-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SuperGen, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |
| US-20090285772-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| EP-2078008-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SuperGen, Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| US-20090099106-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| WO-2009049132-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20080175814-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080146748-A1 | Polyurethane-modified alkyd resin dispersions | BAYER MATERIALSCIENCE AG (DE) | 2008-06-19 | — | — | US | disclosed |
| CN-101186683-A | Polyurethane-modified alkyd resin dispersions | BAYER MATERIALSCIENCE AG (DE) | 2008-05-28 | — | — | CN | disclosed |
| EP-1923411-A2 | Polyurethane modified alkyde resin dispersions | Bayer MaterialScience AG (DE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2008046085-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080175814-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | ESR1 2677/4885LMNA 1408/4885ESR2 2188/4885 |
| US-20110256092-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | ESR1 2677/4885LMNA 1408/4885ESR2 2188/4885 |
| US-20090285772-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | ESR1 2677/4885LMNA 1408/4885ESR2 2188/4885 |
| US-20090099106-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | ESR1 2677/4885LMNA 1408/4885ESR2 2188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.