Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.60 |
| ▸ | ACE | P12821 | 4/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15466952 | 0.93 | MME (0.69) | MMEACECTSA | |
| SCHEMBL19788072 | 0.93 | MME (0.69) | MMEACECTSA | |
| SCHEMBL12481962 | 0.93 | MME (0.69) | MMEACECTSA | |
| SCHEMBL12481917 | 0.85 | MME (0.80) | MMEACEMMEL1 | |
| SCHEMBL11969648 | 0.85 | MME (0.80) | MMEACEMMEL1 | |
| SCHEMBL11969654 | 0.80 | MME (0.53) | MMEACECTSA | |
| SCHEMBL24350626 | 0.80 | MME (0.51) | MMEACEMMEL1 | |
| SCHEMBL21351167 | 0.80 | MME (0.51) | MMEACEMMEL1 | |
| SCHEMBL19688101 | 0.79 | MME (0.58) | MMEACE | |
| SCHEMBL24350873 | 0.79 | MME (0.56) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670186-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-06-06 | — | — | US | disclosed |