Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4936090 | 0.92 | DDB1 (0.45) | KDM4EMEN1PABPC1KMT2AMAPT | |
| SCHEMBL4941226 | 0.88 | DDB1 (0.46) | KDM4EMEN1PABPC1KMT2AMAPT | |
| SCHEMBL18923342 | 0.87 | DDB1 (0.48) | KDM4EMEN1PABPC1KMT2AMAPT | |
| SCHEMBL4940401 | 0.84 | DDB1 (0.49) | KDM4EMEN1PABPC1KMT2ADDB1 | |
| SCHEMBL4931953 | 0.83 | DDB1 (0.47) | KDM4EMEN1PABPC1KMT2ADDB1 | |
| SCHEMBL4937821 | 0.83 | DDB1 (0.45) | KDM4EMEN1PABPC1KMT2AMAPT | |
| SCHEMBL4936700 | 0.83 | DDB1 (0.46) | KDM4EMEN1PABPC1KMT2ADDB1 | |
| SCHEMBL4938866 | 0.82 | DDB1 (0.46) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL4939497 | 0.82 | CRBN (0.42) | DDB1CRBNHDAC1HDAC2 | |
| SCHEMBL4938579 | 0.81 | DDB1 (0.46) | KDM4EMEN1PABPC1KMT2ADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669015-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2017-06-06 | — | — | US | disclosed |