Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | FADS1 | O60427 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20072472 | 0.87 | AXL (0.47) | AXLMKNK1MKNK2PDE4BPDE4A | |
| SCHEMBL6371631 | 0.80 | AXL (0.53) | AXLMKNK1MKNK2PDE4BPDE4A | |
| SCHEMBL12557914 | 0.75 | ADORA2A (0.35) | AXLMKNK1MKNK2PDE4BPDE4A | |
| SCHEMBL19565807 | 0.75 | CHEK1 (0.45) | L3MBTL1MEN1KMT2AAURKB | |
| SCHEMBL21101028 | 0.74 | ADORA2A (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL21362866 | 0.71 | SMN1; SMN2 (0.43) | PDE4BPDE4APDE4CPDE4DADORA2A | |
| SCHEMBL236691 | 0.71 | PDE4A (0.47) | AXLMKNK1MKNK2PDE4BPDE4A | |
| SCHEMBL13955562 | 0.70 | AXL (0.50) | AXLMKNK1MKNK2PDE4BPDE4A | |
| SCHEMBL4572141 | 0.69 | AXL (0.53) | AXLMKNK1MKNK2PDE4BPDE4A | |
| SCHEMBL24292896 | 0.69 | AXL (0.49) | AXLMKNK1MKNK2PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670196-B2 | Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-06-06 | — | — | US | disclosed |