Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726028 | 0.86 | HRH3 (0.88) | HRH3KCNH2GPR119CCR5 | |
| SCHEMBL3670891 | 0.86 | HRH3 (0.88) | HRH3KCNH2GPR119CCR5 | |
| SCHEMBL3636321 | 0.86 | HRH3 (0.65) | HRH3KCNH2GPR119MGLLPOLB | |
| SCHEMBL8368604 | 0.85 | HRH3 (0.70) | HRH3KCNH2GPR119MGLLUSP30 | |
| Hydrochloric Acid SCHEMBL3639931 | 0.85 | HRH3 (0.64) | HRH3KCNH2GPR119MGLLPOLB | |
| SCHEMBL3731699 | 0.83 | HRH3 (0.88) | HRH3KCNH2GPR119MGLLCCR5 | |
| SCHEMBL3727978 | 0.82 | HRH3 (1.00) | HRH3KCNH2GPR119 | |
| SCHEMBL4944133 | 0.82 | HRH3 (1.00) | HRH3KCNH2GPR119 | |
| SCHEMBL22259610 | 0.82 | KMT2A (0.60) | HRH3KCNH2GPR119MGLLALDH1A1 | |
| SCHEMBL3665742 | 0.81 | HRH3 (0.62) | HRH3KCNH2GPR119MGLLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010916-B1 | 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-09-27 | — | — | EP | disclosed |
| US-9670142-B2 | 1,3-diaminocyclopentane carboxamide derivatives | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |