Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.58 |
| ▸ | FER | P16591 | 2/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103681 | 0.91 | SYK (0.71) | SYKFER | |
| SCHEMBL20750869 | 0.87 | FER (0.48) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18926102 | 0.86 | SYK (0.48) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL20750838 | 0.86 | SYK (0.48) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925283 | 0.85 | SYK (0.61) | SYKFER | |
| SCHEMBL18925293 | 0.85 | SYK (0.52) | SYKFER | |
| SCHEMBL18925761 | 0.85 | SYK (0.49) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925674 | 0.84 | SYK (0.59) | SYKFER | |
| SCHEMBL20750800 | 0.83 | SYK (0.57) | SYKFER | |
| SCHEMBL20750718 | 0.83 | SYK (0.49) | SYKFERMAPK3MAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |