Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | FER | P16591 | 6/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925552 | 0.91 | SYK (0.42) | SYKFER | |
| SCHEMBL20750862 | 0.91 | SYK (0.42) | SYKFER | |
| SCHEMBL18925689 | 0.90 | SYK (0.42) | SYKFER | |
| SCHEMBL18925688 | 0.89 | SYK (0.39) | SYKFER | |
| SCHEMBL20750776 | 0.88 | FER (0.51) | SYKFER | |
| SCHEMBL20750777 | 0.88 | FER (0.42) | SYKFER | |
| SCHEMBL18925554 | 0.85 | SYK (0.51) | SYKFER | |
| SCHEMBL2716337 | 0.82 | SYK (0.56) | SYK | |
| SCHEMBL5027635 | 0.80 | SYK (0.53) | SYKIRAK4 | |
| SCHEMBL5028029 | 0.80 | SYK (0.56) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |