Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.57 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028024 | 1.00 | SYK (0.57) | SYKFER | |
| SCHEMBL18925561 | 0.89 | SYK (0.59) | SYKFER | |
| SCHEMBL5028052 | 0.89 | SYK (0.59) | SYKFER | |
| SCHEMBL14977646 | 0.87 | SYK (0.73) | SYK | |
| SCHEMBL5028209 | 0.86 | JAK2 (0.55) | SYKFER | |
| SCHEMBL18925983 | 0.85 | SYK (0.73) | SYKFER | |
| SCHEMBL9110047 | 0.85 | SYK (0.73) | SYKFER | |
| SCHEMBL5028189 | 0.85 | SYK (0.57) | SYK | |
| SCHEMBL9110458 | 0.85 | SYK (0.46) | SYKFER | |
| SCHEMBL5028032 | 0.85 | SYK (0.58) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |