Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 6/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750779 | 0.86 | SYK (0.51) | SYK | |
| SCHEMBL20750718 | 0.84 | SYK (0.49) | SYKJAK2JAK1FERMAPK3 | |
| SCHEMBL20750861 | 0.83 | SYK (0.56) | SYKJAK2KCNH2 | |
| SCHEMBL18925881 | 0.82 | SYK (0.46) | SYKJAK2JAK1MAPK3MAPK1 | |
| SCHEMBL18925609 | 0.77 | JAK1 (0.47) | SYKJAK2JAK1MAPK3MAPK1 | |
| SCHEMBL9109865 | 0.77 | SYK (0.60) | SYKJAK2FERMAPK3MAPK1 | |
| SCHEMBL14910002 | 0.77 | SYK (0.60) | SYKJAK2FERMAPK3MAPK1 | |
| SCHEMBL20750756 | 0.76 | SYK (0.49) | SYKJAK2JAK1FERMAPK3 | |
| SCHEMBL18925343 | 0.75 | SYK (0.49) | SYKJAK2JAK1FERMAPK3 | |
| SCHEMBL3358796 | 0.74 | SYK (0.46) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |