Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713649 | 1.00 | SYK (0.76) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925878 | 0.91 | SYK (0.63) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925983 | 0.89 | SYK (0.73) | SYKFER | |
| SCHEMBL9110047 | 0.89 | SYK (0.73) | SYKFER | |
| SCHEMBL5028031 | 0.88 | SYK (0.61) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL2714489 | 0.87 | SYK (0.77) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18926190 | 0.87 | SYK (0.77) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL1353416 | 0.86 | SYK (1.00) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL2715340 | 0.86 | SYK (0.73) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL2712734 | 0.86 | SYK (0.59) | SYKKCNH2AURKBMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |