Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.47 |
| ▸ | FER | P16591 | 8/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.39 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925818 | 0.96 | SYK (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL20750741 | 0.96 | SYK (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925871 | 0.90 | SYK (0.43) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18926045 | 0.89 | FER (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL20750732 | 0.89 | FER (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925817 | 0.89 | SYK (0.54) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18926189 | 0.86 | SYK (0.52) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925610 | 0.84 | SYK (0.51) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925390 | 0.83 | FER (0.56) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL20750756 | 0.81 | SYK (0.49) | SYKFERMAPK3MAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |