Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.59 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750768 | 1.00 | SYK (0.59) | SYKFEREML4ALK | |
| SCHEMBL18925371 | 0.92 | SYK (0.63) | SYKFER | |
| SCHEMBL18925372 | 0.92 | SYK (0.63) | SYKFER | |
| SCHEMBL2729025 | 0.91 | SYK (0.71) | SYKFEREML4ALK | |
| SCHEMBL18925311 | 0.91 | SYK (0.51) | SYKFER | |
| SCHEMBL20750788 | 0.91 | SYK (0.51) | SYKFER | |
| SCHEMBL20750800 | 0.90 | SYK (0.57) | SYKFEREML4ALK | |
| SCHEMBL18926102 | 0.86 | SYK (0.48) | SYKFER | |
| SCHEMBL20750724 | 0.85 | SYK (0.56) | SYKEML4ALK | |
| SCHEMBL20750869 | 0.85 | FER (0.48) | SYKFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |