Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | FER | P16591 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750744 | 1.00 | SYK (0.50) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL20750878 | 0.95 | SYK (0.50) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL5027550 | 0.89 | SYK (0.50) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL5028060 | 0.87 | SYK (0.60) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL20750756 | 0.86 | SYK (0.49) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL18925610 | 0.86 | SYK (0.51) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL20750881 | 0.86 | SYK (0.45) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL20750747 | 0.86 | SYK (0.61) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL18925658 | 0.86 | SYK (0.45) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL18925379 | 0.86 | SYK (0.61) | SYKMAPK3MAPK1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |