Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 16/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715057 | 0.90 | SYK (0.54) | JAK2JAK1SYKFERKCNH2 | |
| SCHEMBL18926182 | 0.87 | JAK1 (0.50) | JAK2JAK1SYKKCNH2AURKB | |
| SCHEMBL18925323 | 0.82 | SYK (0.46) | JAK2JAK1SYKFERKCNH2 | |
| SCHEMBL5027894 | 0.81 | SYK (0.66) | JAK2SYKFERKCNH2AURKB | |
| SCHEMBL18925541 | 0.80 | SYK (0.49) | JAK2JAK1SYKFERKCNH2 | |
| SCHEMBL18925609 | 0.78 | JAK1 (0.47) | JAK2JAK1SYKKCNH2AURKB | |
| SCHEMBL18926145 | 0.78 | SYK (0.52) | JAK2JAK1SYKFERKCNH2 | |
| SCHEMBL2713892 | 0.77 | SYK (0.55) | JAK2JAK1SYKKCNH2AURKB | |
| SCHEMBL9103616 | 0.77 | SYK (0.54) | JAK2SYKFERKCNH2TYRO3 | |
| SCHEMBL18925772 | 0.76 | SYK (0.49) | JAK2JAK1SYKFERKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |