Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.61 |
| ▸ | FER | P16591 | 8/20 | 0.55 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715340 | 0.91 | SYK (0.73) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925400 | 0.90 | SYK (0.49) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925873 | 0.90 | SYK (0.58) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925878 | 0.87 | SYK (0.63) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18926167 | 0.84 | SYK (0.54) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925321 | 0.84 | SYK (0.51) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18926182 | 0.83 | JAK1 (0.50) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925590 | 0.82 | SYK (0.46) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL9106025 | 0.82 | FER (0.79) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL14909796 | 0.82 | FER (0.79) | SYKKCNH2AURKBMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |