Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.46 |
| ▸ | JAK2 | O60674 | 10/20 | 0.46 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | TYK2 | P29597 | 7/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15556649 | 0.96 | JAK1 (0.44) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL19012321 | 0.92 | FGFR1 (0.43) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL18708660 | 0.87 | JAK1 (0.48) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL15583203 | 0.84 | KDR (0.43) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL15556423 | 0.83 | FGFR1 (0.42) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL15583129 | 0.81 | FGFR1 (0.37) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL22476420 | 0.81 | FGFR1 (0.44) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL18315401 | 0.81 | JAK1 (0.37) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL15557342 | 0.80 | FGFR1 (0.46) | JAK1JAK2JAK3TYK2NTRK1 | |
| SCHEMBL18926210 | 0.78 | KDR (0.41) | JAK1JAK2JAK3TYK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822273-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | Incyte Holdings Corporation (US) | 2021-05-19 | — | — | EP | disclosed |
| EP-3495367-B1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE HOLDINGS CORP (US) | 2020-09-30 | — | — | EP | disclosed |
| EP-3495367-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | Incyte Holdings Corporation (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-2861595-B9 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE HOLDINGS CORP (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-3176170-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | Incyte Holdings Corporation (US) | 2017-06-07 | — | — | EP | disclosed |