Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007707 | 0.85 | POLB (0.81) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL1009425 | 0.84 | TP53 (0.78) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL1007898 | 0.84 | POLB (0.64) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL1007695 | 0.83 | TP53 (0.80) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL8007309 | 0.81 | MAPT (0.76) | TP53POLBSMN1; SMN2MAPTLMNA | |
| SCHEMBL1006939 | 0.81 | TP53 (0.79) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL8009300 | 0.81 | TP53 (0.75) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL1894575 | 0.80 | TP53 (0.78) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL1008134 | 0.80 | POLB (0.64) | TP53POLBSMN1; SMN2TSHRGAA | |
| SCHEMBL1006454 | 0.79 | POLB (0.68) | TP53POLBSMN1; SMN2TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | GRIN1, GRM1, GRIK1 | TP53 3973/4885POLB 3571/4885SMN1; SMN2 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.