Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.80 |
| ▸ | PARP2 | Q9UGN5 | 13/20 | 0.78 |
| ▸ | PARP3 | Q9Y6F1 | 13/20 | 0.78 |
| ▸ | TNKS | O95271 | 1/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.78 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.78 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.78 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.78 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.78 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.78 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.78 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28612193 | 0.89 | PARP1 (1.00) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL1422151 | 0.88 | PARP1 (1.00) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL1421952 | 0.88 | PARP1 (1.00) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL1421875 | 0.88 | PARP1 (1.00) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL567840 | 0.87 | PARP1 (0.98) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL567839 | 0.87 | PARP1 (0.98) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL1422061 | 0.87 | PARP1 (0.98) | PARP1PARP2PARP3TNKSCHRM2 | |
| Niraparib SCHEMBL28370623 | 0.87 | PARP1 (0.98) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL24301101 | 0.86 | PARP1 (0.69) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL21036416 | 0.86 | PARP1 (0.69) | PARP1PARP2PARP3TNKSCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342498-A1 | PARP GENOMIC VARIANTS CONFERRING RESISTANCE AND SENSITIZATION TO CHEMOTHERAPY UNDER INHIBITION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-11-30 | — | — | US | disclosed |
| US-20170157212-A1 | CDK MODULATORS AND METHODS FOR THE TREATMENT OF CANCER | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-06-08 | — | — | US | disclosed |
| US-20170137403-A1 | REGIOSELECTIVE N-2 ARYLATION OF INDAZOLES | MERCK SHARP & DOHME CORP. (US) | 2017-05-18 | — | — | US | disclosed |
| US-9580407-B2 | Regioselective N-2 arylation of indazoles | MERCK SHARP & DOHME CORP. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150299167-A1 | Regioselective N-2 Arylation of Indazoles | MERCK SHARP & DOHME CORP. (US) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342498-A1 | PARP GENOMIC VARIANTS CONFERRING RESISTANCE AND SENSITIZATION TO CHEMOTHERAPY UNDER INHIBITION | PARP8, PARP1, PARP11 | PARP1 2/4885PARP2 4/4885PARP3 6/4885 |
| US-20150299167-A1 | Regioselective N-2 Arylation of Indazoles | PARP2, PARP1, PARP12 | PARP1 2/4885PARP2 1/4885PARP3 5/4885 |
| US-20170137403-A1 | REGIOSELECTIVE N-2 ARYLATION OF INDAZOLES | PARP2, PARP1, PARP12 | PARP1 2/4885PARP2 1/4885PARP3 5/4885 |
| US-20170157212-A1 | CDK MODULATORS AND METHODS FOR THE TREATMENT OF CANCER | CDK12, CDK1, CDKL2 | PARP1 571/4885PARP2 292/4885PARP3 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.