Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | GLS | O94925 | 6/20 | 0.48 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18890144 | 1.00 | PDE10A (0.52) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL18890155 | 0.88 | MAP4K4 (0.52) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL18933448 | 0.88 | MAP4K4 (0.52) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL17296051 | 0.87 | MEN1 (0.55) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL17296049 | 0.87 | MEN1 (0.55) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL22499821 | 0.87 | SYK (0.51) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL952899 | 0.82 | CKS1B (0.51) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL952604 | 0.82 | CKS1B (0.51) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL17295995 | 0.82 | PDE10A (0.52) | PDE10AMAP4K4CKS1BSKP1SKP2 | |
| SCHEMBL17295997 | 0.82 | PDE10A (0.52) | PDE10AMAP4K4CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383872-B1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | CANCER RESEARCH TECH LTD (GB) | 2020-05-20 | — | — | EP | disclosed |
| EP-3383871-B1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-09-11 | — | — | EP | disclosed |
| WO-2017093299-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |
| WO-2017093300-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |
| WO-2017093301-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |