Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469252 | 0.94 | CHRM5 (0.58) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL13874583 | 0.92 | CHRM5 (0.54) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL3440544 | 0.92 | CHRM5 (0.54) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL8318507 | 0.92 | CHRM5 (0.54) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL19155633 | 0.90 | CHRM5 (0.59) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL20927276 | 0.88 | CHRM5 (0.48) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL21094075 | 0.87 | CHRM5 (0.45) | CHRM5ADRA2CACHECYP1A2NCF1 | |
| SCHEMBL10070997 | 0.84 | CHRM5 (0.61) | CHRM5ADRA2CACHECYP1A2CYP2D6 | |
| SCHEMBL18898074 | 0.84 | CHRM5 (0.68) | CHRM5ADRA2CACHECYP1A2HRH3 | |
| SCHEMBL22953689 | 0.84 | CHRM5 (0.61) | CHRM5ADRA2CACHECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633357-B2 | Intermediates and process for preparing intermediates in the production of substituted pyrazolopyridines | ADVERIO PHARMA GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-10364229-B2 | Crystalline substituted 5-fluoro-1H-pyrazolopyridines and process for preparing | ADVERIO PHARMA GMBH (DE) | 2019-07-30 | — | — | US | disclosed |
| US-20180065942-A1 | CRYSTALLINE SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND PROCESS FOR PREPARING | ADVERIO PHARMA GMBH (DE) | 2018-03-08 | — | — | US | disclosed |
| US-9845300-B2 | Process for preparing substituted 5-fluoro-1H-pyrazolopyridines | ADVERIO PHARMA GMBH (DE) | 2017-12-19 | — | — | US | disclosed |
| US-20170158652-A1 | PROCESS FOR PREPARING SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES | ADVERIO PHARMA GMBH (DE) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158652-A1 | PROCESS FOR PREPARING SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES | CYP3A5, CYP4F2, CYP2F1 | CHRM5 488/4885ADRA2C 154/4885ACHE 1265/4885 |
| US-10364229-B2 | Crystalline substituted 5-fluoro-1H-pyrazolopyridines and process for preparing | CYP3A5, CYP2F1, CYP4F2 | CHRM5 217/4885ADRA2C 120/4885ACHE 1271/4885 |
| US-20180065942-A1 | CRYSTALLINE SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND PROCESS FOR PREPARING | CYP3A5, CYP2F1, CYP4F2 | CHRM5 217/4885ADRA2C 120/4885ACHE 1271/4885 |
| US-10633357-B2 | Intermediates and process for preparing intermediates in the production of substituted pyrazolopyridines | CYP3A5, CYP4F2, CYP2F1 | CHRM5 804/4885ADRA2C 392/4885ACHE 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.